随着经济全球化和信息化的深入发展，以质量为核心的标准、人才、技术、市场、资源等竞争日趋激烈。企业必须通过持续的质量改进和知识创新，为实施全面质量管理提供充足动力。全面质量管理和知识创新之关系的研究受到了企业界、学术界广泛重视，但关于该问题的规范研究并不多见。 本文主要采用文献研究法、问卷调查法、实证研究法，通过广泛查阅文献，深入了解国内外研究现状，结合前人的研究成果和陕西省企业实际情况，确定了全面质量管理、知识创新及中介变量的构成要素；以此为基础构建了整体概念模型，并提出了研究假设；接着设计了调查问卷，通过实地调研收集数据，本次调研共向210家陕西省企业发放了235份问卷，回收了218份问卷，问卷回收率为92.77%，其中有效问卷210份，问卷有效率为96.33%；采用结构方程模型与统计分析相结合的办法进行实证研究，最后得出如下结论： 全面质量管理对知识创新和质量文化有正向影响；全面质量管理与知识创新氛围不存在直接影响关系；质量文化和知识创新氛围对知识创新均产生正向影响作用；全面质量管理通过中介变量质量文化对知识创新产生正向影响。

With in-depth development of information technology and economic globalization, the competition of the talents, technology, markets, resources and the standards which takes the quality as the core is becoming intensive. Companies must provide sufficient power for the implementation of total quality management through continuous quality improvement and knowledge innovation. The research of relationship between total quality management and enterprise knowledge innovation attracts widespread attention from the business community and academia, but the standard researches on the issue are rare. In this paper, the author uses methods of literature study, questionnaire, empirical research, through extensive literature review, in-depth understanding of current research, combined with previous research results and the actual situation of enterprises in Shaanxi Province, and determines elements of the total quality management, knowledge innovation and intermediary and variable; The author takes it as a basis to construct the overall conceptual model and proposed research hypotheses, then designed a questionnaire to collect data. Through the practical research, the author sends out 235 questionnaires to 205 enterprises and collects 218 questionnaires, response rate was 92.77%, of which 210 copies of questionnaires are effective, the questionnaires’ effective rate was 96.33%. The author combines the structural equation modeling and statistical analysis method to do the empirical research, and finally draw the following conclusions: Total quality management has positive effect on knowledge of business innovation and quality culture; there is no direct impact on the relationship between total quality management and enterprise knowledge innovation atmosphere; Both the quality of the culture and intellectual atmosphere of innovation will have positive effect on knowledge creation; total quality management through an intermediary Cultural variables has a positive impact on the quality of enterprise knowledge innovation.